• We report our experience using conventional cytogenetic

  2019-09-18

  

  We report our experience using conventional cytogenetic analysis, FISH using EWSR1 break-apart probes, RT-PCR, and Sanger sequencing to detect characteristic translocations in a total of 32 patients with ES diagnosed at Texas Children\'s Hospital over a 5-year interval. Materials and methods R

• Synthetic peptides have proven highly

  2019-09-17

  

  Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to synthetic collagen-like peptides. First, the thermal stability of

• rna polymerase In order to validate the ATP competitive mode

  2019-09-17

  

  In order to validate the ATP competitive mode of inhibition, compound 12 was selected as a representative inhibitor of this series, and the IC50 values were determined at eight different concentrations of compound 12 ranging from 0.001 to 100 μM, and repeated four times using different ATP concentra

• br Particle swarm optimization for NLBP br Computational

  2019-09-17

  

  Particle swarm optimization for NLBP Computational tests Conclusions Acknowledgements This work was supported by the State Key Development Program for Basic Research of China (No. 2009CB421104) and the National Natural Science Foundation of China (Nos. 50809004 & 41071323). Main Text

• br Effects of estrogens on bone Estrogens play

  2019-09-17

  

  Effects of estrogens on bone Estrogens play an important role in bone remodeling, as demonstrated by studies in mice in which the ER genes were deleted [21], [22]. ERβ compensates for the atp citrate lyase inhibitor of ERα, and vice versa, but when both ERs are deleted a profound decrease in tra

• Form the previous literature It was observed that RHA was

  2019-09-17

  

  Form the previous literature, It was observed that RHA was burnt in the range of 500 °C to 700 °C, with high content of quartzite silica was used is a partial replacement of cement in mortar and in concrete. The results shown an excellent behavior in enhancing the mechanical properties of cement mor

• br Conclusion Our study demonstrates

  2019-09-17

  

  Conclusion Our study demonstrates that the effects of Epac activation are strongly conditioned by the steady-state Ca levels at which the myocyte is functioning. As intracellular Ca increases, the activity of CaMKII enhances and the phosphorylation of its SR substrates acquires different relevanc

• br Conclusions br Declaration of interest br Acknowledgement

  2019-09-17

  

  Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads

• The authors identified inhibitors of

  2019-09-17

  

  The authors identified inhibitors of SUMOylation using two assays to monitor the conjugation of SUMO1 to RanGAP1 by E1 and E2 enzymes: a fluorescence resonance energy transfer (FRET) primary screen that evaluated over 250,000 compounds and a chemiluminescence secondary screen. A counter screen was u

• It was reported that the expressions of DPP and

  2019-09-17

  

  It was reported that the expressions of DPP-4 and SDF-1α increase through HIF-1α [27], [28]. Myocardial ischemia by MI enhanced the DPP-4 and SDF-1α levels in myocardium in the present study. SDF-1α is released from cardiomyocytes and has beneficial effects on cardiomyocytes through SDF-1α/CXCR4 aft

• Introduction Maintenance of genome integrity is essential fo

  2019-09-17

  

  Introduction Maintenance of genome integrity is essential for life, and faithful DNA replication and repair ensure this. One of the most important parameters for DNA maintenance is the regulation of optimal concentrations of the four 5′-deoxyribonucleoside-triphosphates (dNTPs) the precursors for D

• br Acknowledgements br Introduction Serum triglyceride conce

  2019-09-17

  

  Acknowledgements Introduction Serum triglyceride concentrations increase following ingestion of a fat containing meal resulting in postprandial hyperlipidemia. Peak serum triglyceride levels are observed within 2 to 4h of fat consumption and then gradually return to baseline levels within appr

• Since anti MMP Therapy anti

  2019-09-17

  

  Since, anti-MMP Therapy [9], anti-iNOS therapy [10], TNF-α and IL-1β inhibitor (Diacerhein) [11] etc. are some of the disease modifying anti-osteoarthritis drugs have been used. But their action based on the evidence from the clinical trial and scientific literature suggesting the therapeutic effica

• Growing evidence has shown that ANS dysregulation indexed

  2019-09-17

  

  Growing evidence has shown that ANS dysregulation, indexed by heart rate variability (HRV), plays a critical role in the pathogenesis of anxiety (Minassian et al., 2014, 2015). Indeed, we have previously reported that patients with GAD are associated with reduced resting parasympathetical (vagal) co

• br Introduction Oral contraceptives OCs are

  2019-09-16

  

  Introduction Oral contraceptives (OCs) are the most commonly used medication for contraception all over the world and are also used in the treatment of menstrual disturbances and hyperandrogenism in women with polycystic ovary syndrome [1]. The impact of OC steroids on cardiovascular pathophysiol

15926 records 955/1062 page Previous Next First page 上5页 951952953954955 下5页 Last page