• Several lines of evidence suggest that thermosensation in

  2021-12-02

  

  Several lines of evidence suggest that thermosensation in AFD is unlikely to be mediated by thermosensitive ion channels. AFD exhibits a steep temperature dependence with a reported Q of >1015 for temperature-evoked current, implying a strong amplification step in the thermotransduction process (Ram

• br Materials and methods br Results

  2021-12-02

  

  Materials and methods Results Discussion GSK-3 overexpression diminishes neurogenesis (Fuster-Matanzo et al., 2013, Kondratiuk et al., 2013, Sirerol-Piquer et al., 2011), while the inhibition of GSK-3 with lithium or valproate enhances neurogenesis, as measured by cell proliferation, the nu

• br Amino acid usage in

  2021-12-02

  

  Amino 2,4-Diacetylphloroglucinol mg usage in cancer Perspective High glucose consumption is a common feature of several types of tumor cells. Therefore, so far, in vivo positron emission tomography (PET) imaging with the glucose analog 18F-fluorodeoxyglucose (18F-FDG) has been used to detect

• Molecular properties as well as metabolic stability in rat a

  2021-12-02

  

  Molecular properties as well as metabolic stability in rat and human liver microsomes for the most active nitro (), nitrile (), methylsulfone (), and sulfonamides () analogues were measured (). All these derivatives possessed excellent membrane permeability as measured in the Pampa assay and further

• These findings raise the question of what mechanism of beta

  2021-12-01

  

  These findings raise the question of what mechanism of beta cell proliferation is induced by short-term HF diet feeding. Gene expression profiling of isolated islets from mice fed a HF diet for 1 week revealed that expression levels of downstream genes of Foxm1 were coordinately upregulated (Fig. 5)

• Somatostatin analogues are among the first peptide based

  2021-12-01

  

  Somatostatin analogues are among the first peptide-based drugs used in cancer imaging and therapy (for review see Reubi, 2003). Treatment of tumors by the use of peptide analogues labeled with cytotoxic agents acting via specific receptors is also under investigation for neuropeptide Y (Koglin and B

• Glucose metabolic pathways are well defined but the subcellu

  2021-12-01

  

  Glucose metabolic pathways are well defined but the subcellular organization of these pathways is poorly understood in liver and kidney. Several factors affect the net flux of gluconeogenesis and allow the rgd peptide to respond to physiological changes [1]. Ovadi and Srere have suggested that a ne

• Accompanied with apoptosis other ways of

  2021-12-01

  

  Accompanied with apoptosis, other ways of neuronal death also occur in ischemic Y27632 receptor due to the impairment of mitochondrial homeostasis [16]. Oxidative DNA damage activates poly (ADP-ribose) polymerase 1 (PARP-1) to induce regulated necrosis, referred to as parthanatos, in the brain [17]

• To identify structurally novel autophagy inhibitors a

  2021-12-01

  

  To identify structurally novel autophagy inhibitors, a medium throughput screen of our in-house library of approximately 160,000 compounds was performed. In the screening assay, MCF7 integrin inhibitors stably transfected with eGFP-tagged light chain 3 (LC3), were employed, which can be detected by

• The first report of GUCY D related gene augmentation therapy

  2021-12-01

  

  The first report of GUCY2D-related gene augmentation therapy in mammalians was also reported in 2006 in the KO mouse model (section 4.1.1). In this study, an AAV5 vector by using AAV5-mediated transfer of the bovine cDNA (the same used in the chicken study) was injected to the post-natal KO retina a

• br Activation of soluble guanylate cyclase The

  2021-12-01

  

  Activation of soluble guanylate cyclase The molecular steps involved in sGC activation have evolved significantly over the last several years. The key studies are outlined below, but here we provide an overall summary. The activation mechanism of sGC was initially proposed to be relatively simple

• To assess the roles of

  2021-12-01

  

  To assess the roles of GPR120 and GPR40 in malignant properties of pancreatic cancer cells, we generated GPR120 and GPR40 knockdown (PANC-sh120 and PANC-sh40, respectively) H-Ser-OH from PANC-1 (Fig. 2A). While no difference of cell growth rate between control PANC-RFP cells and PANC-sh120 cells wa

• In the present study we found that the expression

  2021-12-01

  

  In the present study, we found that the expression of GPR120 in decidua from women of spontaneous abortion was significantly downregulated compared to the decidua from that of normal pregnancy. Moreover, GPR120 deletion (GPR120−/−) or inhibition predisposed mice to LPS or RU486 induced abortion, ind

• br Introduction Over the past two decades the prevalence of

  2021-12-01

  

  Introduction Over the past two decades, the prevalence of obesity and obesity-associated metabolic diseases, such as T2D, insulin resistance, atherosclerosis and stroke, have been dramatically increased globally [1], [2], and obesity has been suggested to be the leading cause of the reduced life

• br Discussion Our results indicate that marked changes in

  2021-11-30

  

  Discussion Our results indicate that marked changes in the relative distribution of AMPA receptors in microsomal and synaptic fractions occur during the postnatal period, and that these changes are correlated with changes in different populations of AMPA binding sites. At early postnatal ages (PN

15926 records 525/1062 page Previous Next First page 上5页 521522523524525 下5页 Last page