• br Introduction Adenosine deaminase ADA which

  2023-02-08

  

  Introduction Adenosine deaminase (ADA), which can catalyze the conversion of AD to inosine by removing an amino group, is a key hydrolytic enzyme of purine metabolism (Conway and Cooke, 1939), and plays an important role in an amount of diseases. For example, an increase of ADA activity in serum

• br Experimental Procedures br Acknowledgments br Introductio

  2023-02-08

  

  Experimental Procedures Acknowledgments Introduction Synapses are fundamental units for efficient communication between neurons and their target cells. Despite significant progress in understanding the structure of matured synapses, less is known about the mechanisms by which neurotransmitt

• br Autophagy and cell death pathways in ischemic stroke Alth

  2023-02-08

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic Gallamine Triethiodide receptor injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great

• br Synthetic lethal approaches In addition to

  2023-02-08

  

  Synthetic lethal approaches In addition to the potential utility of ATM and ATR as chemo- or radiosensitisers, recent studies suggest that such compounds may have single agent activity in certain subsets of patients through induction of synthetic lethality. Two genes are considered synthetically

• Neuropathic animals display increased sensitivity to the

  2023-02-08

  

  Neuropathic animals display increased sensitivity to the anti-nociceptive effect of baclofen and whilst the number and affinity of GABAB catalase inhibitor in the dorsal horn are not altered (Smith et al., 1994; Zemoura et al., 2016), GABAB receptors subunits (B1 and B2) are both down-regulated in

• br Experimental section br Acknowledgements br Introduction

  2023-02-08

  

  Experimental section Acknowledgements Introduction DJ-1 is a highly conserved, homodimeric protein that was originally cloned as an oncogene capable of transforming TAI-1 australia in cooperation with activated ras[1]. DJ-1 is over-expressed in multiple tumor types and is positively correl

• br Discussion br Acknowledgments Writing

  2023-02-08

  

  Discussion Acknowledgments Writing of this review and collection of data from our laboratories that are presented were supported by a grant from the Belgian Science Policy (BELSPO) SSTC Interuniversity Attraction Poles Plastoscine P7/17 to AVDL and JB, multiple grants from the Fund for Scienti

• Mitochondria are key organelles involved in the

  2023-02-08

  

  Mitochondria are key organelles involved in the mechanism of apoptosis (Xiong et al., 2014), and loss of ΔΨm is an important marker associated with mitochondrial dysfunction and cell death. We found that Mino induced ΔΨm impairment and nuclear fragmentation in Jurkat NPS-2143 hydrochloride in a con

• Dopaminergic neurons are vulnerable to oxidative products an

  2023-02-08

  

  Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial hiv protease are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cell dysfunction

• Electron paramagnetic resonance studies of mixtures of

  2023-02-08

  

  Electron paramagnetic resonance studies of mixtures of Aβ1–40 and Aβ1–42 suggest that interlaced fibrils might also form [40] where Aβ1–40 and Aβ1–42 is found within the same fibril. Considering the Aβ fold rather than the sequence, these observations imply two mechanisms that might lower the total

• It has been recognized for

  2023-02-07

  

  It has been recognized for decades that neurons in the mammalian central nervous system may release both a fast-acting, typically amino acid derived neurotransmitter such as glutamate or GABA, and a second peptidergic neuromodulatory molecule such as neuropeptide Y, substance P, or cholecystokinin.

• During the year study period of men in the dutasteride

  2023-02-07

  

  During the 4-year study period, 19.9% of men in the dutasteride group developed prostate cancer as compared to 25.1% in the placebo group, which represents an absolute risk Fluorescein RNA of 5.1% for men taking dutasteride (P 4 year period, reduced the risk of biopsy-detected cancer and also improv

• br Ataxia telangiectasia and Rad related as a therapeutic ta

  2023-02-07

  

  Ataxia–telangiectasia and Rad3 related as a therapeutic target Several concerns revolving around functional inhibition of ATR have hindered the exploitation of ATR as therapeutic target in cancer therapy and delayed the development of specific ATR kinase inhibitors. It was anticipated that pharma

• Physical and chemical preservatives such

  2023-02-07

  

  Physical and chemical preservatives such as ultraviolet and ɣ-rays irradiation, sulphur and aluminium phosphide fumigation, etc, have been introduced to inhibit the growth of fungi. Nevertheless, due to the potential decomposition reactions and residues, as well as their own potential toxicity, and

• The efficacy of antibiotics in improving smell

  2023-02-07

  

  The efficacy of BYL-719 in improving smell function has been previously found to be negative, both when used for bacterial and viral infections. Van Zele et al, in a double-blind, placebo-controlled, multicenter study, found no influence of doxycycline treatment on self-reported olfactory loss in 14

15926 records 322/1062 page Previous Next First page 上5页 321322323324325 下5页 Last page