• Our studies in FMD have led to the discovery

  2018-10-30

  

  Our studies in FMD have led to the discovery of a reductive damaging mechanism in DNA (Wang et al, 2009; Lu, 2010a; Nguyen et al., 2011). More recently, we further demonstrated the reductive damaging mechanism in human lung and skin normal cells, which causes serious reductive DNA damage and genetic

• Matrix metalloproteinases MMPs constitute a principal family

  2018-10-30

  

  Matrix metalloproteinases (MMPs) constitute a principal family of enzymes involved in degradation of ECM proteins. The pathological over-expression of MMPs results in small protein fragments holding PTMs, which are released into the blood. These PTM fragments can be referred to as neoepitopes or so-

• Clinical and epidemiological studies have reported lifetime

  2018-10-30

  

  Clinical and epidemiological studies have reported lifetime prevalence rates for comorbid anxiety disorders in bipolar disorder of 50% (Cassano et al., 1999; Pini et al., 1997; McElroy et al., 2001). The Epidemiological Catchment Area study found the lifetime prevalence for panic disorder in bipolar

• In these issues of Lan and colleagues

  2018-10-30

  

  In these issues of , Lan and colleagues describe vaccine studies in a non-human primate model of MERS-CoV infection (). Building on previous studies in rhesus macaques with SARS-CoV (), the report details the efficacy of a MERS vaccine based on a recombinant orexin binding domain (RBD) subunit. The

• Standard echocardiography contributes to refinement of strok

  2018-10-30

  

  Standard echocardiography contributes to refinement of stroke risk stratification. Moderate–severe LV dysfunction from 2-D echocardiography was the strongest independent predictor of later thromboembolism (The Stroke Prevention in Atrial Fibrillation Investigators, 1992). LV hypertrophy, defined as

• CBD and CVD risks were markedly

  2018-10-30

  

  CBD and CVD risks were markedly elevated, but only for mortality. Heat causes an increase in cardiac output, redistributes blood flow away from core organs, attenuates vasodilatation and sweat rate, and increases the potential for thrombosis (Keatinge et al., 1986). These responses are worsened by t

• The gene was cloned in and

  2018-10-30

  

  The gene was cloned in 1990 and initial studies of the large complex gene identified only between 30 and 65% of germline mutations in clearly affected individuals (Shen et al., 1996). Furthermore, phenotype analysis in pedigrees suggested that there would be little significant genotype–phenotype cor

• Then all calculations were performed using R

  2018-10-29

  

  Then, all calculations were performed using R v.3.1.1 (R Development Core Team, 2011; http://cran.r-project.org) [1]. Experimental design, materials and methods In metabolic profiling, there is no single platform or method to analyze the entire metabolome of a biological sample, mainly due to th

• br The coefficient of resistance to humidity Crh is defined

  2018-10-29

  

  The coefficient of resistance to humidity (Crh) is defined with respect to the resistance to crushing after five cycles of alternate watering and drying and the resistance to the simple smoothened when dried. Crh: Coefficient of resistance to humidity, σmsa: The resistance to humid compression

• br Experimental design materials and methods br Acknowledgem

  2018-10-29

  

  Experimental design, materials and methods Acknowledgements This research was supported by the Knut & Alice Wallenberg Foundation via the Wallenberg Wood Science Center, the Swedish Research Council Formas via CarboMat, and the European Research Council through Grant 336355 (“MicroDE”). The au

• br Experimental design The dataset presented here

  2018-10-29

  

  Experimental design The dataset presented here was obtained from using the label-free proteomic analysis of three different strains of Prototheca species, P. zopfii genotype 1, genotype 2 and P. blaschkeae representing non-infectious, infectious and moderately infectious strains, respectively. In

• nos inhibitor Items were adapted or generated

  2018-10-29

  

  Items were adapted or generated, based on a selection of established theories and scales related to the nine preliminary sub-goals. Generated items were formulated based on our understanding of the theories related to the given goal, while adapted items were based on the content of established scale

• The class that we assign

  2018-10-29

  

  The class that we assign to each daily record is 1 if the subsequent day is favorable for intra-day trading and 0 otherwise. Favorable for intra-day trading means that the increase between the opening price and the closing price of the same day is large enough for obtaining a profit by buying at the

• In the decades since Yarbus vivid demonstration numerous

  2018-10-29

  

  In the decades since Yarbus’ vivid demonstration, numerous studies have corroborated the fact that one’s eyes are generally directed towards the object of one’s thoughts (Ferreira et al., 2008; Just and Carpenter, 1980, 1976; Theeuwes et al., 2009; Thomas and Lleras, 2007; Van der Stigchel et al., 2

• br Discussion LCH is an extremely rare disease

  2018-10-29

  

  Discussion LCH is an extremely rare disease with unknown etiology associated with aberrant proliferation of Langerhans cells, a member of the monocyte–macrophage system located primarily in the bone marrow. LCH is usually encountered as a childhood disease, with a general rate of 1/200,000 in chi

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