• To explain this effect of GAG mimetics on bone regeneration

  2018-11-12

  

  To explain this effect of GAG mimetics on bone regeneration, we hypothesize that it is partly due to their capacity to modulate endogenous MSC properties in vivo. Therefore, to validate this secretin receptor we investigated in this study whether some particular mimetics are able to potentiate effe

• AG-14361 Several pancreatic cancer cell lines and human tiss

  2018-11-12

  

  Several pancreatic cancer cell lines and human tissue samples were surveyed for cell surface, intracellular, and functional markers. CD20, CD24, CD44, CD133, CD184 (CXCR4), CD326 (EpCam), Sox-2, and OCT3/4 were examined in established pancreatic cancer cell lines. The functional marker, i.e., SP, wa

• Although H AZK me could be

  2018-11-12

  

  Although H2AZK7me1 could be detected by ChIP at the transcriptional start site of a few differentiation markers (Fgf5, FoxA2, and Hand2) in E14 mES cells and the level of methylation decreased from those genes in response to retinoic acid-induced differentiation, we still do not know what H2AZK7me1

• br Conclusions This unique technique

  2018-11-12

  

  Conclusions This unique technique developed in rats allows in less than 15min to biopsy olfactory mucosa, without significant impairment in odor discrimination. We show here that olfactory stem cells can be expanded in vitro. It should however be pointed out that the same technique can be used fo

• While M macrophages may be the principal drivers of angiogen

  2018-11-12

  

  While M2 macrophages may be the principal drivers of angiogenesis associated with injury resolution, M1 macrophages are highly fibrolytic, which may facilitate angiogenesis, and secrete pro-angiogenic factors such as TNFα and IL-1β, and nitric oxide (Sunderkotter et al., 1994; Cooke & Losordo, 2002)

• Since the analysis of a complete motor unit

  2018-11-12

  

  Since the analysis of a complete motor unit is essential for the understanding of pathophysiological mechanisms of motoneuron diseases (Moloney et al., 2014), or conditions involving the NMJ, we established an in vitro model of motor units. To that end, we cultivated hiPSC cell lines from healthy co

• SDCs and GPCs have been

  2018-11-12

  

  SDCs and GPCs have been reported to regulate cell adhesion, migration and differentiation and demonstrate specific expression and localisation during CNS development (Choi et al., 2011, Ford-Perriss et al., 2003). The depletion of SDC1, GPC1 and GPC4 in vitro in mouse NSC or neural precursor cells a

• Here we describe the characteristics of a novel SeVdp iPS

  2018-11-09

  

  Here, we describe the characteristics of a novel SeVdp-iPS vector (SeVdp(KOSM)302L) containing miR-302a target sequences at the 3′-UTR of the L gene. This vector can be used for the efficient reprogramming of MEFs into transgene-free iPSCs without the aid of siRNAs, observed using human embryonic fi

• Human liver chimeric mice carrying human pHH can

  2018-11-09

  

  Human liver chimeric mice carrying human pHH can facilitate in vivo study of viral hepatitis infections (Bissig et al., 2010; Carpentier et al., 2014) and liver genetic diseases (Bissig-Choisat et al., 2015; Yusa et al., 2011), and the testing of small molecular drug candidates and biological compon

• Thbs can induce apoptosis via

  2018-11-09

  

  Thbs1 can induce apoptosis via upregulation of active caspase-3 (Li et al., 2003). Consistently, Lxn−/− HSCs demonstrated decreased apoptosis and reduced levels of active caspase-3, suggesting that downregulation of Thbs1 might also intrinsically enhance Lxn−/− stem cell survival (Figure 7G). An inc

• pitavastatin While the results of the

  2018-11-09

  

  While the results of the membrane-based γ-secretase assays are not consistent with a direct effect on the core γ-secretase complex, there are indirect ways by which APP proteolysis may be altered that could go undetected in a cell-free assay. The specific APP processing paths leading to the generati

• Specific transcriptional networks play an essential role in

  2018-11-09

  

  Specific transcriptional networks play an essential role in sustaining the growth and self-renewal of embryonic stem order Chloroquine (ESCs) and neoplastic stem-like cells. Expression of a defined and limited set of transcription factors (i.e., SOX2, OCT3/4, NANOG, KLF4, C-MYC, and BMI1) can repro

• br The function r is determined from the integral equation

  2018-11-09

  

  The function β (r) is determined from the integral equation the core of which has the form In the case when 0, the formulae (4) are transformed into the known Terezawa\'s solution [9]. Concentrated force applied to an elastically fixed boundary of the half-space For the transition in the s

• br The connection between the yield point of a

  2018-11-09

  

  The connection between the yield point of a material and the surface tension aldose reductase of its particles As follows from Fig. 1, the surface tension coefficient rapidly decreases with a decrease in the particle size R/δ of the material, for particles with sizes less than 20δ (about 20nm).

• 2-deoxy-d-glucose br Acknowledgments br Introduction Thermal

  2018-11-09

  

  Acknowledgments Introduction Thermal air convection in closed and tilted rectangular cavities is of interest due to the fact that containers of this type are the elements in a great number of technical devices. Their orientation can change smoothly or stepwise, while the convective flows in th

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