• br Conclusions This unique technique

  2018-11-12

  

  Conclusions This unique technique developed in rats allows in less than 15min to biopsy olfactory mucosa, without significant impairment in odor discrimination. We show here that olfactory stem cells can be expanded in vitro. It should however be pointed out that the same technique can be used fo

• While M macrophages may be the principal drivers of angiogen

  2018-11-12

  

  While M2 macrophages may be the principal drivers of angiogenesis associated with injury resolution, M1 macrophages are highly fibrolytic, which may facilitate angiogenesis, and secrete pro-angiogenic factors such as TNFα and IL-1β, and nitric oxide (Sunderkotter et al., 1994; Cooke & Losordo, 2002)

• Since the analysis of a complete motor unit

  2018-11-12

  

  Since the analysis of a complete motor unit is essential for the understanding of pathophysiological mechanisms of motoneuron diseases (Moloney et al., 2014), or conditions involving the NMJ, we established an in vitro model of motor units. To that end, we cultivated hiPSC cell lines from healthy co

• SDCs and GPCs have been

  2018-11-12

  

  SDCs and GPCs have been reported to regulate cell adhesion, migration and differentiation and demonstrate specific expression and localisation during CNS development (Choi et al., 2011, Ford-Perriss et al., 2003). The depletion of SDC1, GPC1 and GPC4 in vitro in mouse NSC or neural precursor cells a

• Here we describe the characteristics of a novel SeVdp iPS

  2018-11-09

  

  Here, we describe the characteristics of a novel SeVdp-iPS vector (SeVdp(KOSM)302L) containing miR-302a target sequences at the 3′-UTR of the L gene. This vector can be used for the efficient reprogramming of MEFs into transgene-free iPSCs without the aid of siRNAs, observed using human embryonic fi

• Human liver chimeric mice carrying human pHH can

  2018-11-09

  

  Human liver chimeric mice carrying human pHH can facilitate in vivo study of viral hepatitis infections (Bissig et al., 2010; Carpentier et al., 2014) and liver genetic diseases (Bissig-Choisat et al., 2015; Yusa et al., 2011), and the testing of small molecular drug candidates and biological compon

• Thbs can induce apoptosis via

  2018-11-09

  

  Thbs1 can induce apoptosis via upregulation of active caspase-3 (Li et al., 2003). Consistently, Lxn−/− HSCs demonstrated decreased apoptosis and reduced levels of active caspase-3, suggesting that downregulation of Thbs1 might also intrinsically enhance Lxn−/− stem cell survival (Figure 7G). An inc

• pitavastatin While the results of the

  2018-11-09

  

  While the results of the membrane-based γ-secretase assays are not consistent with a direct effect on the core γ-secretase complex, there are indirect ways by which APP proteolysis may be altered that could go undetected in a cell-free assay. The specific APP processing paths leading to the generati

• Specific transcriptional networks play an essential role in

  2018-11-09

  

  Specific transcriptional networks play an essential role in sustaining the growth and self-renewal of embryonic stem order Chloroquine (ESCs) and neoplastic stem-like cells. Expression of a defined and limited set of transcription factors (i.e., SOX2, OCT3/4, NANOG, KLF4, C-MYC, and BMI1) can repro

• br The function r is determined from the integral equation

  2018-11-09

  

  The function β (r) is determined from the integral equation the core of which has the form In the case when 0, the formulae (4) are transformed into the known Terezawa\'s solution [9]. Concentrated force applied to an elastically fixed boundary of the half-space For the transition in the s

• br The connection between the yield point of a

  2018-11-09

  

  The connection between the yield point of a material and the surface tension aldose reductase of its particles As follows from Fig. 1, the surface tension coefficient rapidly decreases with a decrease in the particle size R/δ of the material, for particles with sizes less than 20δ (about 20nm).

• 2-deoxy-d-glucose br Acknowledgments br Introduction Thermal

  2018-11-09

  

  Acknowledgments Introduction Thermal air convection in closed and tilted rectangular cavities is of interest due to the fact that containers of this type are the elements in a great number of technical devices. Their orientation can change smoothly or stepwise, while the convective flows in th

• tamoxifen citrate In conclusion extending results of prior a

  2018-11-09

  

  In conclusion, extending results of prior analyses (Grossman & Jacobwitz, 1981; Corman & Grossman, 1985; Joyce, 1987a, 1987b; Meier & McFarlane, 1994; McFarlane & Meier, 1998, 2001), our study provides contemporary evidence that state-only expenditures for reproductive services tamoxifen citrate fo

• In vivo data generated using

  2018-11-09

  

  In vivo data generated using hCD40Tg animals further demonstrate that antigen targeting to CD40 is an efficient way to evoke antigen-specific CD8+ T cell responses in vivo. Although we could not compare CD40 with LOX-1 or Dectin-1 in this animal model due to the limited specificities of mAbs (αLOX-1

• A multi biomarker based outcome

  2018-11-09

  

  A multi-biomarker based outcome stratification model has also been advocated by Wong et al. that reliably estimated probability of mortality based on inflammatory markers along with conventional clinical and demographic data. Similar to our approach the sensitivity is much better than the specificit

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