• br Author contributions br Acknowledgments This work was sup

  2020-07-30

  

  Author contributions Acknowledgments This work was supported by the Polish National Science Center grant SONATA [2012/07/D/NZ4/00814] and by the Ministry of Sciences and Higher Education [556/MOB/2009/0]. Introduction Oral contraceptives (OCs) are one of the most widely used drugs by women

• 2189 Since corticotropin releasing factor CRF was isolated

  2020-07-30

  

  Since corticotropin-releasing factor (CRF) was isolated and characterized as the major physiological regulator of the hypothalamus-pituitary-adrenal gland axis and was shown to be responsible for the coordination of the endocrine, autonomic and behavioral responses associated with stress (Vale et al

• Due to its therapeutic applications in the treatment of canc

  2020-07-30

  

  Due to its therapeutic applications in the treatment of cancer and autoimmune diseases, a robust understanding of the molecular determinants of CPG2 activity is of great interest for further development of therapeutics and applications. However, apart from an X-ray crystal structure of unliganded CP

• cpg was isolated in a screen

  2020-07-30

  

  cpg2 was isolated in a screen for seizure-induced genes and is regulated by physiological activity Nedivi et al. 1993, Nedivi et al. 1996. In general, screens for activity-regulated genes have isolated a number of synaptic proteins that are the components of the basic transmission machinery, indicat

• br Results and discussion As explained

  2020-07-30

  

  Results and discussion As explained in detail in the Theory section, one of the highly recommended approaches in thermodynamics to model vapor-liquid equilibria at low pressure conditions is the γ−ϕ approach. Following this approach, in order to have greatly reliable results for the challenging s

• Topological spaces are assumed to be connected

  2020-07-30

  

  Topological spaces are assumed to be connected for any consideration of cut points. The concept of COTS (=connected ordered topological space), defined by Khalimsky, Kopperman and Meyer [5], does not require any separation axiom. In view of the applications of cut points (see e.g. [5]) and the fact

• Third DGK protein stabilization by

  2020-07-29

  

  Third, DGKδ2 protein stabilization by myristic Calpeptin mg is cell line specific. Myristic acid had no obvious effects on DGKδ protein stability in the liver cell line HepG2, pancreas cell line MIA-PaCa-2 and neuronal cell line Neuro-2a cells (Fig. 5). Although myristic acid moderately increased th

• Introduction DHFR is an important enzyme in both

  2020-07-29

  

  Introduction DHFR is an important enzyme in both mammals and microorganism including Mycobacterium tuberculosis (Mtb). It catalyzes folic BCTC conversion to dihydro and tetrahydro folic acid which is a crucial step in folate pathway [1]. Inhibition of folate pathway leads to interruption of thymid

• We have previously shown that the receptor

  2020-07-29

  

  We have previously shown that the receptor for advanced glycation end products (RAGE) is expressed by JW 55 in-vitro and in-vivo and that a RAGE ligand interferes with calvarial bone healing [53]. Combined with the current study, an understanding emerges that AGE-modification of collagen inhibits bi

• The role of DDR in glomerular injury

  2020-07-29

  

  The role of DDR1 in glomerular injury has been then further studied by the Chatziantoniou group in experimentally-induced crescentic glomerulonephritis, by injection of alloimmune sheep nephrotoxic serum (NTS) [54]. Glomerulonephritis produced a 17-fold increase of DDR1 expression, predominantly in

• Udenafil is a novel PDE inhibitor that has an established

  2020-07-29

  

  Udenafil is a novel PDE5 inhibitor that has an established record of safety and efficacy in adult males for the indication of erectile dysfunction., , In that population, the pharmacokinetics (PK) of udenafil (molecular weight 516 g/mol) and the major circulating metabolite, DA-8164 (molecular weigh

• What are the molecular signals that guide

  2020-07-28

  

  What are the molecular signals that guide Tfh cells as they navigate around the lymph node in the course of the immune response? It was recently reported that Tfh cells inside GCs have high expression of SIPR2, which acts to repel them from the S1P-rich lymph in the SCS and promote their retention i

• A structural model for the unprecedented interactions

  2020-07-28

  

  A structural model for the unprecedented interactions between UBE2S, its target (i.e., a Ub that has been linked already to an APC/C substrate), and APC/C was generated by hybrid structural studies merging information from NMR, crosslinking, and mutational data with a low-resolution cryo-EM map of A

• DCPIB In the case of high fidelity polymerases

  2020-07-28

  

  In the case of high-fidelity polymerases, we propose that water is used to achieve negative selection against nucleotide binding. With specialized DNA polymerases, we propose that nucleobase desolvation plays a different yet important role in allowing these enzymes to replicate damaged DNA. In this

• The reduced DNA stability at RH

  2020-07-28

  

  The reduced DNA stability at 100% RH confirms previous results for incubates at these conditions, although in the present study amplifiable DNA still survived for months. The crucial point appears to be the onset of microbial growth, which happened at room temperature and at 35 °C. In the biological

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