• hyPerFUsion™ high-fidelity DNA polymerase sale br Materials

  2022-05-09

  

  Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the hyPerFUsion™ high-fidelity DNA polymerase sale of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato

• Anti apoptotic Bcl proteins have become attractive targets

  2022-05-09

  

  Anti-apoptotic Bcl-2 proteins have become attractive targets for anti-cancer agents development, because they are associated with progression of a wide variety of human cancers., , The small-molecular Bcl-2 inhibitor venetoclax (ABT-199) () has been approved recently for the treatment of patients w

• Hepatitis C virus HCV is a frequent cause of infectious

  2022-05-09

  

  Hepatitis C virus (HCV) is a frequent cause of infectious chronic hepatitis. Unlike hepatitis A and B, there is no vaccine to prevent hepatitis C infection yet. According to WHO, around 200 million people are infected with HCV worldwide [1], in addition to three to four million newly infected patien

• Hypoxia has been shown to

  2022-05-07

  

  Hypoxia has been shown to affect miR-155 expression that can induce autophagy in nasopharyngeal and cervical carcinoma cells [334]. Suppression of miR-155 inhibited hypoxia-induced autophagy. miR-155 targeted mRNAs involved in the PI3K/PTEN/Akt/mTORC1 pathway including: Ras homolog enriched in metho

• br Methods br Results br Discussion

  2022-05-07

  

  Methods Results Discussion Our results show that the DRG and the spinal cord express significant amount of GPR35, a previously orphan Gi protein coupled receptor whose stimulation with zaprinast or with KYNA may reduce inflammatory pain. The receptor is also expressed in primary cultures of

• br Introduction Inflammatory bowel diseases IBDs

  2022-05-07

  

  Introduction Inflammatory bowel diseases (IBDs) including Crohn's disease and ulcerative colitis (Baumgart and Sandborn, 2012; Beaugerie et al., 2006) are typically characterized by chronic, progressive, and relapsing inflammation of the intestine. Although the exact pathogenesis of IBD is unknow

• The action of niacin in upregulating cAMP is

  2022-05-07

  

  The action of niacin in upregulating cAMP is most likely determined by the milieu of adenylyl cyclase isoforms expressed in macrophages that are responsive to GPR109A activation. Several adenylyl cyclase isoforms, namely AC2, AC4 and AC7, are responsive to the stimulatory action of Gβγ G-protein sub

• br Acknowledgements This work was supported by Slovak Academ

  2022-05-07

  

  Acknowledgements This work was supported by Slovak Academy of Sciences grants VEGA 2/0052/10 and 2/0045/10. Both clinical observations and preclinical studies suggest that hypofunction of -methyl--aspartate (NMDA) receptor is implicated in the pathophysiology of schizophrenia. Thus, therapeuti

• Finally we investigated if calpain truncation affects

  2022-05-07

  

  Finally, we investigated if calpain truncation affects GlyT1 turnover and trafficking. To simulate calpain cleavage at the T602/T603 and G626/S627 sites we constructed GlyT1 transporters missing the last 12 and 36 amino acids. Since the 36 amino tgf beta receptor 1 truncation also removes all C-term

• Due to the therapeutic potential of GlyT inhibitors numerous

  2022-05-07

  

  Due to the therapeutic potential of GlyT1 inhibitors, numerous drug screening campaigns have been started - and are still going on - which aimed at the identification of compounds with biological activity at or affinity for this drug target. For characterization of biological activity at GlyT1, tran

• Finally the results in this article indicate that

  2022-05-07

  

  Finally, the results in this article indicate that atomistic MD in conjunction with computational electrophysiology and ion-permeation simulations provide a useful tool for the functional annotation of ion-channel structures. In particular, they exemplify how MD simulations in native lipid membranes

• br Regulation of Glu transporters The pivotal role of

  2022-05-07

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino L-703,664 succinate calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include

• br Experimental methods br Acknowledgments We thank all

  2022-05-07

  

  Experimental methods Acknowledgments We thank all members of the Hermanson lab, especially Ana Teixeira, Shirin Ilkhanizadeh and Karolina Wallenborg, for assistance and discussions, Peter Löw for anti-synaptotagmin antibody, and Lars Björklund, Ole Isacson, Christer Höög, Claes Wahlestedt and

• In the present study we characterized

  2022-05-07

  

  In the present study, we characterized the expression of glucose transporters in the developing and adult mouse lens and showed that GLUT1 is the primary transporter expressed in the lens epithelium. We found that mice with a homozygous deletion of Slc2a1 from the lens epithelium developed cataracts

• Because of the relationship between carbohydrate consumption

  2022-05-07

  

  Because of the relationship between carbohydrate consumption and chronic diseases such as obesity and type II diabetes (Hu, van Dam, & Liu, 2001), there is mounting interest to evaluate the quality of ack1 inhibitor through analysis by glycemic index (GI) and Englyst assay, for example (Englyst, Ki

15981 records 438/1066 page Previous Next First page 上5页 436437438439440 下5页 Last page