• Glycogen synthase kinase GSK is currently

  2022-08-05

  

  Glycogen synthase kinase 3 (GSK3) is currently considered to be a multifunctional serine/threonine kinase involved in a wide spectrum of cellular processes such as glycogen metabolism, cell proliferation, neuronal function, oncogenesis or embryonic development (for recent reviews see: Rayasam et al.

• Elimination of the Q R bridge significantly affected the

  2022-08-05

  

  Elimination of the Q234–R244 bridge significantly affected the protein energy metabolism but had little effect on its activity at a permissive temperature, which may seem contrary to the known functional importance of this motif in Fpg. However, since the mutants fully or partially retained the boun

• Based on our finding that TFA modulates GlyR function and

  2022-08-05

  

  Based on our finding that TFA modulates GlyR function and reports that TFA-bound Kif15-IN-2 can differ markedly from those synthesized without TFA, we retested a previously published dodecapeptide (D12-116) that also enhanced GlyR function but this time as a chloride salt (Tipps et al., 2010). No d

• Excessive extracellular glutamate may induce

  2022-08-05

  

  Excessive extracellular glutamate may induce excitotoxic neuronal damage in disorders of the CNS (Schwartz et al., 2003). EAATs are considered to contribute to prevention of excitotoxicity by glutamate uptake. Our data revealed that expression levels of membrane EAAT proteins in astrocytes are much

• The association between mental disorders and smoking was fir

  2022-08-05

  

  The association between mental disorders and smoking was firmly established, and their inter-relationship was due to the reciprocal causal effects (Tjora et al., 2014). Previous research found that negative affect and the urge to smoke as well as the urge to smoke and nicotine dependence had signifi

• br Genetic rescue of GluR A dependent spatial working memory

  2022-08-05

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific PRT062607 Hydrochloride of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et

• Because of the relationship between carbohydrate consumption

  2022-08-05

  

  Because of the relationship between carbohydrate consumption and chronic diseases such as obesity and type II diabetes (Hu, van Dam, & Liu, 2001), there is mounting interest to evaluate the quality of hexokinase regulation through analysis by glycemic index (GI) and Englyst assay, for example (Engl

• MRcKO mice showed a comparable degree of cardiac

  2022-08-05

  

  MRcKO mice showed a comparable degree of cardiac remodeling compared to control (MRf/f) mice. Moreover, the worse cardiac remodeling in pressure-overloaded GRcKO mice is not due to compensatory activation of cardiomyocyte MR, because GRMRdcKO mice displayed cardiac remodeling to the same extent as G

• Rare mutations can impair the molecular

  2022-08-05

  

  Rare mutations can impair the molecular function of GR and alter tissue sensitivity to GCs in humans, resulting in primary generalized GC resistance (PGGR) and hypersensitivity (PGGH) [14]. Familial and sporadic PGGR, or Chrousos Syndrome, is characterized by general and partial insensitivity of tis

• Tacedinaline It is important to underline that although ghre

  2022-08-05

  

  It is important to underline that Tacedinaline although ghrelin increases the motivation to eat even in fed state, its effects on food intake and reward are blunted in obese animal models (Zigman et al., 2016). This emphasizes also the interconnection between homeostatic regulation of food intake a

• Sickle erythrocytes are known to have an increased adhesion

  2022-08-05

  

  Sickle erythrocytes are known to have an increased adhesion to endothelial Ranolazine (Hebbel et al., 1980, Hebbel et al., 1981a, Hebbel et al., 1981b, Wautier et al., 1985, Mohandas and Evans, 1987). Understanding the events associated with vaso-occlusion requires a detailed knowledge of the inter

• Analysis of the i motif structures during biased unfolding

  2022-08-05

  

  Analysis of the i-motif structures during biased unfolding of G-quadruplexes leads to the conclusion that at acidic pH the i-motif is absolutely unaffected by that process. The hydrogen bonds within the i-motif are intact (Fig. 3D) and they only fluctuate around mean values. On the other hand, the i

• Sumoylation is involved in regulating protein

  2022-08-04

  

  Sumoylation is involved in regulating protein-protein interactions, subcellular protein localization, protein stability, and transcriptional factor activity (reviewed in [29]). The small ubiquitin-like modifier (SUMO) protein is covalently attached to a lysine residue in a Ψ-K-X-D/E consensus sequen

• Interestingly evidence has emerged recently that

  2022-08-04

  

  Interestingly, evidence has emerged recently that suggests noncanonical roles of EZH2 in various cancers. For example, in addition to histone H3, EZH2 has been shown to methylate non-histone substrates, such as Jarid2 and STAT3, to regulate their transcriptional activities (He et al., 2012, Sanulli

• Hyperactivation of Notch pathway can

  2022-08-04

  

  Hyperactivation of Notch1 pathway can give rise to transformation into T-ALL in murine models. In more than 50% of acute T-cell lymphoblastic leukemias oncogenic activating mutations of Notch1 have been detected and inactivation of Notch1 signaling impairs leukemia cell proliferation and promotes ap

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