• In conclusion our results show

  2022-08-19

  

  In conclusion, our results show that P7C3 enhances endogenous neurogenesis by upregulating the generation of endogenous neuroblasts and neural stem/progenitor cells by increasing the expression of neuroprotective proteins (Bcl-2, ki67, DCX, adam11, adamts20, and β-tub3) by activation of the cAMP/PKA

• Even though for almost years GnRH was

  2022-08-18

  

  Even though for almost 30 years GnRH was considered the main neuropeptide regulating gonadotropin release in vertebrates, Tsutsui et al. (2000) discovered, in the Japanese quail, Coturnix japonica, a hypothalamic neuropeptide that directly inhibits gonadotropin release, and thus named as gonadotropi

• The GlyR is pentameric with each subunit

  2022-08-18

  

  The GlyR is pentameric, with each subunit consisting of an extracellular ligand binding domain (LBD), four transmembrane (TM) segments, and a large intracellular loop between TM3 and TM4. Binding of neurotransmitter produces conformational changes that are rapidly transmitted to the membrane-spannin

• br Materials and methods br Results br Discussion

  2022-08-18

  

  Materials and methods Results Discussion In the CNS, GLP-1R is associated with G-protein signal transduction pathways, which can activate adenylyl cyclase and protein kinase A by cyclic adenosine monophosphate, and mediates neuronal activities implicated in various pathophysiological change

• Prednisone Such responses have led to the idea that elasmobr

  2022-08-18

  

  Such responses have led to the idea that elasmobranchs may be glucose intolerant. However, certain species, such as the North Pacific spiny dogfish (Squalus suckleyi; note that the species used in this study was previously referred to as Squalus acanthias but a study by Ebert et al. (2010) provided

• br Acknowledgments br Introduction Postmenopausal osteoporos

  2022-08-18

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by DRB sale deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30% of p

• br Results and Discussion br STAR Methods br Author

  2022-08-18

  

  Results and Discussion STAR★Methods Author Contributions Conflicts of Interest J.P.F. is a consultant for AstraZeneca, BMS, Johnson and Johnson, Novo Nordisk, and Sanofi, a member of the advisory panel for AstraZeneca and Sanofi, a member of the speaker’s bureau for Sanofi and Novo Nordi

• Here we used chemogenetic modulation

  2022-08-18

  

  Here, we used chemogenetic modulation of MBH GHSR neurons to address the role of the endogenous ghrelin system in the normal, hyperphagic response to a short-term fast. Studies demonstrating the requirement of an intact ghrelin-GHSR system for the rebound food intake following fasting have been inco

• Another key component of proper DA cell physiology is

  2022-08-18

  

  Another key component of proper DA cell physiology is the basal firing activity of SN DA neurons, which maintains extracellular levels of dopamine in the dorsal striatum that are essential for voluntary movement [106]. Changes in SN DA neuron activity directly impacts the amount of dopamine released

• Different responses in feed intake have been

  2022-08-18

  

  Different responses in feed intake have been noticed following administration of exogenous GHRL (peripherally or centrally) depending on animal species. In mammals, injection of GHRL stimulates food intake (orexigenic effect) (reviewed in Kaiya et al., 2013b). In contrast, in domestic birds, exogeno

• Numerical models of blood regulation provide insight into th

  2022-08-18

  

  Numerical models of blood regulation provide insight into the interaction of the cellular-level and macro-scale phenomena studied in silico, a term referring to computer simulations of the dynamics of complex biological systems as opposed to in vivo or in vitro experimental studies. These in silico

• Cx mimetic peptides short synthetic peptides corresponding t

  2022-08-18

  

  Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino AKT inhibitor VIII sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel function in

• Hydantoin in region F bridging the phenoxybenzene and benzim

  2022-08-18

  

  Hydantoin in region F bridging the phenoxybenzene and benzimidazole moieties was replaced by cyclic building blocks, diketopiperazine (25) and imidazolidinone (26), and linear bonds, amide (27) and urea (28). Analogs 25–28 possessing the linkers other than hydantoin were not tolerated in LBD of FXR,

• br Materials and methods br Results br Discussion FFAR

  2022-08-18

  

  Materials and methods Results Discussion FFAR4 is a G-protein coupled free fatty ML347 receptor that has been reported to be expressed in osteoclasts and osteoblasts [18]. In this study the role of FFAR4 on the effects of different classes of UFAs, the ω−6 PUFA, AA, the ω−3 PUFAs, DHA and

• It has been reported that aberrant GPR expressions were

  2022-08-18

  

  It has been reported that aberrant GPR120 expressions were detected in colorectal carcinomas, compared with normal tissues. In addition, GPR120 stimulated cell motile activity and angiogenic property in colon cancer cells [10]. Recently, we indicated that GPR40 suppressed cell motile and invasive ac

15312 records 333/1021 page Previous Next First page 上5页 331332333334335 下5页 Last page