• The relationship between the apelinergic

  2023-08-10

  

  The relationship between the apelinergic and opioid systems has been previously reported (Lv et al., 2011, Yang et al., 2010). Lv and colleagues showed that naloxone has a suppressive effect on apelin-induced depression-like behavior in mice (Lv et al., 2012a). Furthermore, heterodimerization of GPC

• Gene regulation of MMPs is

  2023-08-10

  

  Gene regulation of MMPs is influenced by the transcription factor activating factor-1 (AP-1). AP-1 complexes are heterodimers of proteins of the two proto-oncogene families (jun and fos) and have ghrelin receptor in the promoter region of MMPs, as well as in genes mediating inflammatory responses.

• serine protease inhibitor br Acknowledgments This work was s

  2023-08-10

  

  Acknowledgments This work was supported by grants from the “Agence Nationale de la Recherche” ANR-09-CESA-006 program, the Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (Anses, Project n° 2012-2-077) and the Interdisciplinary Program “Longévité et Viei

• br Conclusion These studies broadly demonstrate

  2023-08-10

  

  Conclusion These studies broadly demonstrate that dopamine and endocannabinoid signaling in the NAc can have diverse effects on AMPAR-mediated synaptic function depending on previous psychostimulant experience. Here, we examined mechanisms underlying the depotentiation of AMPAR-mediated synaptic

• Analysis of the enzyme activity expressed as rate of product

  2023-08-10

  

  Analysis of the enzyme activity, expressed as rate of product formation per unit serum volume (20μl), between the diagnostic groups revealed that ApB activity was significantly decreased in the patient group both at recruitment and after 13months when the substrate concentration used was 1.5mM (pICI

• Recently rather than predicting categorical

  2023-08-10

  

  Recently, rather than predicting categorical variables as in classification, several studies begin to estimate continuous clinical variables from lipoxygenase inhibitor images. Therefore, instead of classify a subject into binary or multiple pre-determined categories or stages of the disease, regres

• Through systematic deletion of AhR in

  2023-08-10

  

  Through systematic Triciribine of AhR in specific cell types, Di Meglio et al. (2014) revealed that AhR in keratinocytes and fibroblasts are key to the exacerbated psoriatic phenotype induced by IMQ in AhR-deficient mice. This emphasizes the crosstalk between keratinocytes and the immune system to r

• Lipotoxicity is the accumulation of excess

  2023-08-10

  

  Lipotoxicity is the accumulation of excess lipids in non-adipose tissues that leads to cell dysfunction or cell death. It may play an important role in the pathogenesis of diabetes, and contributes to the rate of progression of CKD [7,8]. Emerging evidence indicates that renal lipid dysregulation is

• br Mechanisms of specific immunotherapy Several mechanisms m

  2023-08-10

  

  Mechanisms of specific immunotherapy Several mechanisms may be involved in specific immunotherapy of EAMG by active immunization with the therapeutic vaccine in IFA. During the therapy, the therapeutic benefits result from diversion of autoantibody specificities away from pathogenic extracellular

• To date the modes of actions of pharmaceuticals in

  2023-08-10

  

  To date, the modes of actions of pharmaceuticals in humans and mammals are well-known (Fent et al., 2006), whereas knowledge of aquatic organisms, particularly invertebrates, is limited. This is problematic as these contaminants/pollutants have potentially harmful effects on wildlife organisms that

• Thiomyristoyl br Colorectal carcinoma The growth rate of mur

  2023-07-01

  

  Colorectal carcinoma The growth rate of murine colon adenocarcinoma tumors decreased upon inhibition of 5-LOX, an enzyme that harbors counteracting properties to 15-LOX [28]. It is not clear whether 15-LOX was associated with this phenomenon, but its expression is induced in the colon carcinoma c

• From an historical perspective ligands for GPCRs adrenaline

  2023-06-30

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, Folinic acid or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous ligands we

• br Materials and methods br

  2023-06-28

  

  Materials and methods Results Discussion In this study, the orphan receptor GPR25 was cloned from several representative vertebrate species including zebrafish. Although the overall amino L-Arabinose sequence identity among these species is not high (38–52%), our synteny analysis clearly i

• Thus far a tight coupling has been observed

  2023-06-26

  

  Thus far, a tight coupling has been observed between mAbs that target aggregated Aβ and the occurrence of ARIA. If ARIA-E is caused by increased trafficking to and clearance of fibrillar Aβ from cerebral vessels (20), mAbs could be designed with conformationally specific epitopes selective for solub

• Hepatic inflammation and fibrosis are hallmarks of the

  2023-06-25

  

  Hepatic nox4 and fibrosis are hallmarks of the NASH phenotype and are thought to occur in a subset of patients with NAFLD. While it is hypothesized that therapeutic lowering of hepatic lipids will be sufficient to improve hepatic fibrosis and inflammation secondarily, this remains controversial and

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