• To derive hiPSC from patient

  2018-11-06

  

  To derive hiPSC from patient fibroblasts, we adopted previous protocols (Okita et al., 2011; Rasmussen et al., 2014) and electroporated the patient\'s skin fibroblasts with episomal plasmids expressing human OCT4, SOX2, L-MYC, KLF4, NANOG, LIN28, and short hairpin RNA against TP53. To demonstrate th

• Transforming growth factor TGF signaling is closely related

  2018-11-05

  

  Transforming growth factor β (TGF-β) signaling is closely related to DNA damage repair regulation (Mitra et al., 2013). Studies have shown that TGF-β signaling can suppress BRCA1-dependent repair of DSBs (Dubrovska et al., 2005). Activin A, a member of the TGF-β superfamily of cytokines, interacts w

• Dedifferentiation has been considered as one of the

  2018-11-05

  

  Dedifferentiation has been considered as one of the mechanisms rerouting cell fate by reverting differentiated cells to an earlier, more primitive phenotype. Interestingly, previous studies from both our group and others have demonstrated that dedifferentiation is a prerequisite for bone marrow stro

• br Introduction Stem cells support tissue homeostasis throug

  2018-11-05

  

  Introduction Stem cells support tissue homeostasis through continual production of differentiating progeny based on the maintenance of an undifferentiated cell pool. This is traditionally thought to depend on a couple of paradigmatic mechanisms: asymmetric cell division, which always gives rise t

• br Introduction Retinoblastoma is the most common

  2018-11-05

  

  Introduction Retinoblastoma is the most common primary intraocular pediatric cancer, with 95% of the cases diagnosed before 5 years of age (Kivela, 2009). Retinoblastoma is initiated by biallelic inactivation of the retinoblastoma 1 (RB1) gene. In heritable retinoblastoma, a primary germline muta

• Analysis of the data in Fig b shows

  2018-11-05

  

  Analysis of the data in Fig. 3b shows that the shape of the (222) reflection virtually does not change and corresponds to the instrumental resolution at all temperatures. The right shoulder of the (310) peak exhibits slight differences from the instrumental resolution even at high temperatures, whic

• The initial BC concentration in the resulting colloidal susp

  2018-11-05

  

  The initial BC concentration in the resulting colloidal suspension (BC CS), determined by GSK2194069 to constant weight, was w2=0.305g/g. The subsequent samples of aqueous BC CS with lower BC concentrations were obtained by adding distilled water to the initial colloidal suspension. The initial BC

• Children s frequent references to conversations with peers

  2018-11-05

  

  Children\'s frequent references to conversations with peers and families also resonate closely with Nutbeam\'s (2000) dimension of interactive health literacy: the ability to communicate health needs and interact to address health issues (Harris et al., 2015, p. 3). Their accounts showed that such c

• br Conclusion br Acknowledgements br Introduction About wome

  2018-11-05

  

  Conclusion Acknowledgements Introduction About 265,000 women served in the U.S. military during the Vietnam era, with as many as 11,000 deployed to the Vietnam theater of operations (precise figures are not available) (Thomas, Kang, and Dalager, 1991; http://www.vietnamwomensmemorial.org/vw

• Yet the emphasis on the

  2018-11-05

  

  Yet, the emphasis on the social and/or political purpose of timebanking may have obscured the fact that they are, at the core, exchange networks. TBs are created to offer a space for exchanges of services between individuals, even though the TB may encourage other activities, such as social gatherin

• Among many biosorbents tested fungal biomasses have proved t

  2018-11-05

  

  Among many biosorbents tested, fungal biomasses have proved to possess excellent metal uptake potential (Kapoor and Viraraghavan, 1995; Arvind et al., 2014). Other microbial biosorbents such as algae have also been extensively studied and others such as spiriruna have been commercialized for heavy m

• For the mass fractionation in isotopic ratio analysis i

  2018-11-05

  

  For the mass fractionation in isotopic ratio analysis (i.e., isotopic fractionation), it is mainly affected by the isotopic mass of the analyzed element. For example, the measured lithium isotopic ratio by MC-ICP-MS can deviate from the referred values by up to 25% (Millot et al., 2004; Taylor et al

• Categorization of AD in the epidemiological simulations diff

  2018-11-05

  

  Categorization of AD in the epidemiological simulations differs from some previous studies for China and the US (Wang et al., 2008; AA, 2015) which employed a three-state (mild, moderate, severe) categorization. The current two-state specification of AD (stage 1 and stage 2) encapsulates mild and mo

• Previous work showed that lncRNAs show higher tissue

  2018-11-05

  

  Previous work showed that lncRNAs show higher tissue specificity compared to mRNAs (). The work of Ching et al. supported this notion, and extended it by showing a reduction of specificity after malignant transformation, which is consistent with the de-differentiation status of cancers widely observ

• Introduction In st century the century

  2018-11-05

  

  Introduction In 21st century, the century when the humanity hopes to embark on interplanetary travel, we are yet to fully reach an understanding of our very own idiosyncratic terra incognita – the human sleep. Sleep is a highly conserved evolutionary process that constitutes approximately one third

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